'Til Death centers on Eddie and Joy Stark, and their life, relationship and behavior after 23 years of marriage. The first two seasons often focus on the conflict between the Starks and their newlywed neighbors, Jeff and Steph Woodcock (Eddie Kaye Thomas and Kat Foster). The second season introduces a new character named Kenny Westchester (J. B. Smoove) who is Eddie's friend from the Big Brothers Organization.
The third season focuses primarily on Eddie and Joy's relationship with Kenny after he moves in with them.
The fourth and final season focuses on the Starks coping with life with their daughter Ally (Lindsey Broad, then Kate Micucci) and new son-in-law Doug (Timm Sharp), who live in a biodiesel-powered Airstream motorhome in the Starks' backyard. The series takes place in suburban Philadelphia in Cheltenham Township.