Slither is a 2006 American science fiction comedy horror film written and directed by James Gunn in his directoral debut. It stars Nathan Fillion, Elizabeth Banks, Gregg Henry, and Michael Rooker. The film was produced by Paul Brooks and Eric Newman. The film has similar themes and concepts as the 1986 B-movie Night of the Creeps.
Slither was a box office bomb, but received generally positive reviews from critics and has since become a cult film.