The show was created by Abby Mann, an Academy Award-winning film writer best known for his work on drama anthologies such as Robert Montgomery Presents and Playhouse 90. Universal Television approached him to do a story based on the 1963 Wylie-Hoffert Career Girls Murders, the brutal rape and murder of two young professional women in Manhattan.
Owing to poor police work and the prevailing casual attitude toward suspects' civil rights, the crimes in the Wylie-Hoffert case were pinned on a young African-American man, George Whitmore, Jr., who had been arrested on a separate assault charge. After illegally obtaining a confession, the police had the suspect all but convicted until a second investigation by a different team of detectives exonerated the suspect and identified the real killer, a Puerto Rican drug addict.
Mann developed the project as a gritty police procedural, but with a subtext focusing on institutionalized prejudice and the civil rights of suspects and witnesses. The result was the 1973 made-for-TV movie, The Marcus-Nelson Murders. The opening and closing titles of the film emphasized the point that it was a fictional account of the events that led to the creation of Miranda rights by the U.S. Supreme Court in 1966. Selwyn Raab's book Justice in the Back Room provided Mann with some of his inspiration for the story of The Marcus-Nelson Murders, and the series subsequently included a credits reference to having been "suggested by a book by Selwyn Raab".
Savalas starred in The Marcus-Nelson Murders as a police detective whose last name was spelled "Kojack". The film served as a pilot for the Kojak television series. Kojak himself was a composite character, based on a number of detectives, lawyers, and reporters who were involved in the Wylie-Hoffert murder case.